Vitamin B15 is still a controversial “vitamin” because it has not yet been proven shown to be essential in the diet, and it does not exhibit any symptoms or deficiency diseases in the absence of vitamin B15 in the diet.
The Soviet Union and the European countries has been the most enthusiastic about Pangamic acid because they are feeling that it is a very important nutrient in treating a physiological actions that can treat a multitude of symptoms and diseases. Their scientists have shown that Pangamic supplementation can reduce the build up of lactic acid in sportsmen and thereby lessen muscle fatigue and increase endurance. It is used regularly in these countries for treating various problems such as alcoholism and drug addiction, mental problems such as those of aging and senility, minimal brain damage in children, autism, and schizophrenia, heart disease and high blood pressure, diabetes, skin diseases, liver disease, and chemical poisonings.
The FDA has banned Pangamic acid products from the US markets. So, this vitamin B15 is not available in America but their people use Dimethylglycine (DMG) as a substitute to increase Pangamic acid production in the body.
You do not experience any toxicity symptoms of vitamin B15 in your body even at higher amounts of 50 to 100 mg thrice a day because this will not exhibit any symptoms showing deficiency. Suppose if it exhibits some symptoms, it lasts for only few days. The symptom can be mild nausea if you take pangamates at higher levels.
There is limited information about deficiencies of Pangamic acid because research is still going on. Though some diminished circulatory and oxygenation functions are possible if there is an absence of vitamin B15 in your diet that is decreased cell respiration—that is, decreased oxygen use by cells—may influence many other cellular functions which may lead to effects on the heart.